NFL 2022 Week 1 Odds, Matchups, Picks And Betting Insight

The NFL kicked off the 2022 season with the Super Bowl favorite Buffalo Bills dominating the second half to beat the reigning Super Bowl champion Los Angeles Rams, 31-10. The Bills win was the most lopsided kickoff game in nine years.

The betting action was mostly on the Bills, who rolled up 413 yards offense at 7.1 yards per play to 243 yards and 3.7 yards per play for the Rams. The Bills converted 9-of-10 on third down and Bills QB Josh Allen (+450) increased his MVP odds as favorite after completing 26-of-31 passes for 297 yards and 2 TDs plus a rushing touchdown while leading

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